Product Name :
Dehydrocorydaline nitrate
Description:
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
CAS:
13005-09-9
Molecular Weight:
428.44
Formula:
C22H24N2O7
Chemical Name:
2, 3, 9, 10-tetramethoxy-13-methyl-5, 6-dihydroisoquinolino[2, 1-b]isoquinolin-7-ium;nitrate
Smiles :
CC1C2C3=CC(OC)=C(C=C3CC[N+]=2C=C2C=1C=CC(OC)=C2OC)OC.[O-][N+]([O-])=O
InChiKey:
CZZFYGAXGATDNG-UHFFFAOYSA-N
InChi :
InChI=1S/C22H24NO4.NO3/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23;2-1(3)4/h6-7,10-12H,8-9H2,1-5H3;/q+1;-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Tacrine} web|{Tacrine} Neuronal Signaling|{Tacrine} Purity & Documentation|{Tacrine} In Vitro|{Tacrine} custom synthesis|{Tacrine} Autophagy}
Additional information:
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.{{Rocatinlimab} web|{Rocatinlimab} Protocol|{Rocatinlimab} In Vivo|{Rocatinlimab} manufacturer|{Rocatinlimab} Autophagy} T.PMID:32096671 Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.|Product information|CAS Number: 13005-09-9|Molecular Weight: 428.44|Formula: C22H24N2O7|Synonym:|13-Methylpalmatine nitrate|Chemical Name: 2, 3, 9, 10-tetramethoxy-13-methyl-5, 6-dihydroisoquinolino[2, 1-b]isoquinolin-7-ium;nitrate|Smiles: CC1C2C3=CC(OC)=C(C=C3CC[N+]=2C=C2C=1C=CC(OC)=C2OC)OC.[O-][N+]([O-])=O|InChiKey: CZZFYGAXGATDNG-UHFFFAOYSA-N|InChi: InChI=1S/C22H24NO4.NO3/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23;2-1(3)4/h6-7,10-12H,8-9H2,1-5H3;/q+1;-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85.Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36.Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. doi: 10.1186/s12936-018-2392-4.Products are for research use only. Not for human use.|
