Product Name :
Rabbit anti-KLF15 Polyclonal Antibody(C-term)
Synonym :
Krueppel-like factor 15; Kidney-enriched krueppel-like factor; KLF15; KKLF
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This KLF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-398 amino acids from the C-terminal region of human KLF15.
Predicted Reactivity:
Mouse
Applications :
WB~~1:1000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long time storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cardiovascular;Others
Background :
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
UniProt :
Q9UIH9
Additional information:
Product Details FAQ Citations(1) Video Pictures Documents |Overview |Synonym Krueppel-like factor 15; Kidney-enriched krueppel-like factor; KLF15; KKLF |Host Rabbit |Specificity This KLF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-398 amino acids from the C-terminal region of human KLF15. |Species Reactivity Human |Predicted Reactivity Mouse |Applications WB~~1:1000 |Properties |Clonality Polyclonal Antibody |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long time storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cardiovascular;Others |Target |Background Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. |Cellular localization Nucleus |UniProt Q9UIH9 |References |References Yamamoto, K., et al. Biochem. Biophys. Res. Commun. 400(1):175-180(2010)Haldar, S.M., et al. Sci Transl Med 2 (26), 26RA26 (2010) :Li, J., et al. BMC Genet. 11, 12 (2010) :Du, X., et al. J. Clin. Endocrinol. Metab. 94(7):2594-2601(2009)Wang, B., et al. J. Mol. Cell. Cardiol. 45(2):193-197(2008) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-KLF15 Polyclonal Antibody(C-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
188125-42-0 MedChemExpress 6823-69-4 Technical Information PMID:29494119 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
