Product Name :
PD 144418
Description:
PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity.
CAS:
154130-99-1
Molecular Weight:
282.38
Formula:
C18H22N2O
Chemical Name:
5-[3-(4-methylphenyl)-1, 2-oxazol-5-yl]-1-propyl-1, 2, 3, 6-tetrahydropyridine
Smiles :
CC1C=CC(=CC=1)C1C=C(ON=1)C1CN(CCC=1)CCC
InChiKey:
FOQRKFCLRMMKAT-UHFFFAOYSA-N
InChi :
InChI=1S/C18H22N2O/c1-3-10-20-11-4-5-16(13-20)18-12-17(19-21-18)15-8-6-14(2)7-9-15/h5-9,12H,3-4,10-11,13H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity.|Product information|CAS Number: 154130-99-1|Molecular Weight: 282.38|Formula: C18H22N2O|Chemical Name: 5-[3-(4-methylphenyl)-1, 2-oxazol-5-yl]-1-propyl-1, 2, 3, 6-tetrahydropyridine|Smiles: CC1C=CC(=CC=1)C1C=C(ON=1)C1CN(CCC=1)CCC|InChiKey: FOQRKFCLRMMKAT-UHFFFAOYSA-N|InChi: InChI=1S/C18H22N2O/c1-3-10-20-11-4-5-16(13-20)18-12-17(19-21-18)15-8-6-14(2)7-9-15/h5-9,12H,3-4,10-11,13H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Arterolane manufacturer |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions.DOTATATE supplier PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis.PMID:34973118 |In Vivo:|PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED50 values of 7.0 mg/kg i.p..|Products are for research use only. Not for human use.|
