Product Name :
Isoliquiritin apioside
Description:
Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.
CAS:
120926-46-7
Molecular Weight:
550.51
Formula:
C26H30O13
Chemical Name:
(2E)-3-(4-{[(2S, 3R, 4S, 5S, 6R)-3-{[(2S, 3R, 4R)-3, 4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one
Smiles :
OC1=CC(O)=C(C=C1)C(=O)/C=C/C1C=CC(=CC=1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@](O)(CO)[C@H]1O
InChiKey:
VMMVZVPAYFZNBM-KVFWHIKKSA-N
InChi :
InChI=1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-5-1-13(2-6-15)3-8-17(30)16-7-4-14(29)9-18(16)31/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB.{{Voclosporin} MedChemExpress|{Voclosporin} Phosphatase|{Voclosporin} Purity & Documentation|{Voclosporin} In Vivo|{Voclosporin} custom synthesis|{Voclosporin} Autophagy} Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.{{Ruxolitinib} MedChemExpress|{Ruxolitinib} Epigenetics|{Ruxolitinib} Biological Activity|{Ruxolitinib} References|{Ruxolitinib} custom synthesis|{Ruxolitinib} Autophagy} |Product information|CAS Number: 120926-46-7|Molecular Weight: 550.PMID:32750794 51|Formula: C26H30O13|Chemical Name: (2E)-3-(4-{[(2S, 3R, 4S, 5S, 6R)-3-{[(2S, 3R, 4R)-3, 4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one|Smiles: OC1=CC(O)=C(C=C1)C(=O)/C=C/C1C=CC(=CC=1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@](O)(CO)[C@H]1O|InChiKey: VMMVZVPAYFZNBM-KVFWHIKKSA-N|InChi: InChI=1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-5-1-13(2-6-15)3-8-17(30)16-7-4-14(29)9-18(16)31/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity.|References:|Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.Products are for research use only. Not for human use.|
