BO J. 30: 42744286. 15. Rong R, Ahn J, Huang H, Nagata E, Kalman D, et al. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, stopping neuronal apoptosis. Nat. Neurosci. 6: 11531161. 16. Tang X, Jang S, Okada M, Chan C, Feng Y, et al. Netrin-1 mediates neuronal survival by means of PIKE-L interaction with all the dependence receptor UNC5B. Nat. Cell Biol. ten: 698706. 17. Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, et al. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein four.1N. Cell 103: 919930. 18. Rong YS, Golic KG A targeted gene knockout in Drosophila. Genetics 157: 13071312. 19. Huang J, Zhou W, Watson AM, Jan Y, Hong Y Efficient ends-out gene targeting in Drosophila. Genetics 180: 703707. 20. Xu K, Zheng X, Sehgal A Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 8: 289300. 21. Xia C, Ma W, Stafford LJ, Liu C, Gong L, et al. GGAPs, a brand new loved ones of bifunctional GTP-binding and GTPase-activating proteins. Mol. Cell. Biol. 23: 24762488. ten 18204824 Drosophila PIKE Regulates Developmental Timing 22. Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, et al. A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J. Cell Biol. 172: 497504. 23. Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, et al. The developmental transcriptome of Drosophila melanogaster. Nature 471: 473479. 24. Fuss B, Becker T, Zinke I, Hoch M The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444: 945948. 25. Teleman AA, Chen Y, Cohen SM Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9: 271281. 26. Musselman LP, Fink JL, Narzinski K, Ramachandran PV, Hathiramani SS, et al. A high-sugar diet regime produces obesity and insulin resistance in 
wildtype Drosophila. Dis Model Mech four: 842849. 27. Fletcher JC, Thummel CS The Drosophila E74 gene is needed for the correct stage- and tissue-specific transcription of BTZ043 site ecdysone-regulated genes in the onset of metamorphosis. Development 121: 14111421. 28. Karim FD, Thummel CS Ecdysone coordinates the timing and amounts of E74A and E74B transcription in Drosophila. Genes Dev. five: 10671079. 29. Layalle S, Arquier N, Leopold P The TOR pathway couples nutrition and developmental timing in Drosophila. Dev. Cell 15: 568577. 30. Caldwell PE, Walkiewicz M, Stern M Ras activity within the Drosophila prothoracic gland regulates body size and developmental rate by way of ecdysone release. Curr. Biol. 15: 17851795. 31. Orme MH, Leevers SJ Flies on steroids: the interplay among ecdysone and insulin signaling. Cell Metab. 2: 277278. 32. McBrayer Z, Ono H, Shimell M, Parvy J, Beckstead RB, et al. Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev. Cell 13: 857871. 33. Thummel CS Flies on steroids–Drosophila metamorphosis and also the mechanisms of steroid hormone action. Trends Genet. 12: 306310. 34. Thummel CS Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev. Cell 1: 453465. 35. Davis MB, Carney GE, Robertson AE, Bender M Phenotypic 57773-63-4 evaluation of EcR-A mutants suggests that EcR isoforms have distinctive functions throughout Drosophila improvement. Dev. Biol. 282: 385396. 36. Schubiger M, Wade AA, Carney GE, Truman JW, Bender M Drosophila EcR-B ecdysone receptor isoforms are needed for larval molting and for neuron remodeling throughout metamorphosis. Development 125: 20532062. 37. Bialecki M, Sh.BO J. 30: 42744286. 15. Rong R, Ahn J, Huang H, Nagata E, Kalman D, et al. PI3 kinase enhancer-Homer complicated couples mGluRI to PI3 kinase, stopping neuronal apoptosis. Nat. Neurosci. 6: 11531161. 16. Tang X, Jang S, Okada M, Chan C, Feng Y, et al. Netrin-1 mediates neuronal survival by means of PIKE-L interaction with the dependence receptor UNC5B. Nat. Cell Biol. ten: 698706. 17. Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, et al. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103: 919930. 18. Rong YS, Golic KG A targeted gene knockout in Drosophila. Genetics 157: 13071312. 19. Huang J, Zhou W, Watson AM, Jan Y, Hong Y Effective ends-out gene targeting in Drosophila. Genetics 180: 703707. 20. Xu K, Zheng X, Sehgal A Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. eight: 289300. 21. Xia C, Ma W, Stafford LJ, Liu C, Gong L, et al. GGAPs, a new family members of bifunctional GTP-binding and GTPase-activating proteins. Mol. Cell. Biol. 23: 24762488. 10 18204824 Drosophila PIKE Regulates Developmental Timing 22. Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, et al. A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear physique formation and degradation of expanded polyglutamine protein. J. Cell Biol. 172: 497504. 23. Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, et al. The developmental transcriptome of Drosophila melanogaster. Nature 471: 473479. 24. Fuss B, Becker T, Zinke I, Hoch M The cytohesin Steppke is crucial for insulin signalling in Drosophila. Nature 444: 945948. 25. Teleman AA, Chen Y, Cohen SM Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9: 271281. 26. Musselman LP, Fink JL, Narzinski K, Ramachandran PV, Hathiramani SS, et al. A high-sugar diet regime produces obesity and insulin resistance in wildtype Drosophila. Dis Model Mech four: 842849. 27. Fletcher JC, Thummel CS The Drosophila E74 gene is essential for the proper stage- and tissue-specific transcription of ecdysone-regulated genes at the onset of metamorphosis. Development 121: 14111421. 28. Karim FD, Thummel CS Ecdysone coordinates the timing and amounts of E74A and E74B transcription in Drosophila. Genes Dev. 5: 10671079. 29. Layalle S, Arquier N, Leopold P The TOR pathway couples nutrition and developmental timing in Drosophila. Dev. Cell 15: 568577. 30. Caldwell PE, Walkiewicz M, Stern M Ras activity within the Drosophila prothoracic gland regulates body size and developmental price through ecdysone release. Curr. Biol. 15: 17851795. 31. Orme MH, Leevers SJ Flies on steroids: the interplay amongst ecdysone and insulin signaling. Cell Metab. two: 277278. 32. McBrayer Z, Ono H, Shimell M, Parvy J, Beckstead RB, et al. Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev. Cell 13: 857871. 33. Thummel CS Flies on steroids–Drosophila metamorphosis as well as the mechanisms of steroid hormone action. Trends Genet. 12: 306310. 34. Thummel CS Molecular mechanisms of developmental timing 
in C. elegans and Drosophila. Dev. Cell 1: 453465. 35. Davis MB, Carney GE, Robertson AE, Bender M Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have one of a kind functions for the duration of Drosophila improvement. Dev. Biol. 282: 385396. 36. Schubiger M, Wade AA, Carney GE, Truman JW, Bender M Drosophila EcR-B ecdysone receptor isoforms are expected for larval molting and for neuron remodeling for the duration of metamorphosis. Improvement 125: 20532062. 37. Bialecki M, Sh.
