Self-expanding metallic stents for relieving malignant colorectal obstruction: a systematic overview. Ann Surg 2007; 246: 24-30 [PMID: 17592286] Targownik LE, Spiegel BM, Sack J, Hines OJ, Dulai GS, Gralnek IM, Farrell JJ. Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision evaluation. Gastrointest Endosc 2004; 60: 865-874 [PMID: 15604999] Sagar J. Colorectal stents for the management of malignant colonic obstructions. Cochrane Database Syst Rev 2011; (11): CD007378 [PMID: 22071835 DOI: 10.1002/14651858] Zhang Y, Shi J, Shi B, Song CY, Xie WF, Chen YX. Selfexpanding metallic stent as a bridge to surgery versus emergency surgery for obstructive colorectal cancer: a meta-analysis. Surg Endosc 2012; 26: 110-119 [PMID: 21789642 DOI: ten.1007/ s00464-011-1835-6] Lee HJ, Hong SP, Cheon JH, Kim TI, Min BS, Kim NK, Kim WH. Long-term outcome of palliative therapy for malignant colorectal obstruction in sufferers with unresectable metastatic colorectal cancers: endoscopic stenting versus surgery. Gastrointest Endosc 2011; 73: 535-542 [PMID: 21257165 DOI: ten.1016/j.gie.2010.10.052] Stefanidis D, Brown K, Nazario H, Trevino HH, Ferral H, Brady CE, Gross GW, Postoak DW, Chadhury R, Rousseau DL, Kahlenberg MS. Safety and efficacy of metallic stents within the management of colorectal obstruction. JSLS 2005; 9: 454-459 [PMID: 16381366]COMMENTS COMMENTSBackgroundColorectal tumors may possibly bring about large bowel obstruction and in such instances they call for instant treatment. The mortality rate of emergency surgery is high. Having said that, colonic stents are becoming safely employed in malignant colorectal obstruction within the majority of instances with superior clinical benefits. They may be applied for two indications in colorectal malignancies; palliative dilatation of sophisticated illness, and preoperative decompression as a bridge to surgery. In both indications, colonic stents protect against colostomy with stoma.9Research frontiersColorectal stents might be used for two indications in colorectal malignancies; palliative dilatation of sophisticated disease, and preoperative decompression as a bridge to surgery.IL-34 Protein medchemexpress In both indications, colonic stents avert colostomy with stoma.Innovations and breakthroughsThe authors proved the efficacy and security of colonic stents in each bridge to surgery and for palliative decompression.VHL Protein supplier Moreover, the significance from the abilities of the endoscopist in colonic stenting was also exposed.PMID:24982871 Decompression from the bowel offers time for surgeons to stabilize and prepare the patient for further therapy approaches.ApplicationsColorectal stents are employed increasingly as a nonsurgical alternative for the palliation of luminal gastrointestinal neoplasms. In addition they have an emerging part within the remedy of obstruction in gastrointestinal segments.TerminologyA colostomy is often a surgically designed opening around the abdomen which enables stools to exit the physique.Peer-reviewThe manuscript describes the evaluation of colonic stents. The manuscript is effectively presented and tackles an essential aspect in clinical colon cancer biology. A significant group of nearly 50 individuals happen to be studied. Statistical evaluation is effectively carried out.
Antibiotics 2015, 4, 397-410; doi:10.3390/antibioticsOPEN ACCESSantibioticsISSN 2079-6382 www.mdpi/journal/antibiotics ArticleIdentification of Further Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug LibraryJie Feng, Megan Weitner, Wanliang Shi, Shuo Zhang, David Sullivan and Ying Zhang Department o.
