7 0.78 0.67 1.03** 0.25 0.71** 0.87* 0.67* -0.34 0.57 0.83 0.59 0.61 0.03 0.81* 0.62 0.36 0.66 0.57 0.57 0.46 0.66* 0.68* 0.62 0.47 0.42 0.38 0.37 0.39 1.23 0.63* 0.44 0.97 0.74* 0.05 0.66*Paxbp1 Smim11 SodPAX3 and PAX7 binding protein 1 Smaller integral membrane protein 11 Superoxide dismutase 1, soluble0.27 -0.24 0.0.69 0.76 0.0.66* -0.13 0.0.38 -0.39 -0.Hippocampus Actg1 Atp5o Actin, gamma, cytoplasmic 1 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit Bromodomain and WD repeat domain containing 1 Carbonyl reductase 1 Downstream neighbor of SON Dopey loved ones member two Erythroid differentiation regulator 1 High mobility group nucleosomal binding domain 1 Interferon (alpha and beta) receptor 1 1415779_s_at 1416278_a_at 1437164_x_at 1427322_at Brwd1 1433955_at 1452322_a_at Cbr1 Donson Dopey2 Erdr1 Hmgn1 Ifnar1 1460196_at 1426739_at 1428330_at 1439200_x_at 1452406_x_at 1422495_a_at 1449026_at 1427691_a_at Ifnar2 Interferon (alpha and beta) receptor two 1440169_x_at 1451462_a_at Itgb8 Itsn1 Kcnj6 Morc3 Integrin beta eight Intersectin 1 (SH3 domain protein 1A) Potassium inwardly-rectifying channel, subfamily J, member six Microrchidia 3 1436223_at 1421192_a_at 1425899_a_at 1425707_a_at 1420091_s_at 1452224_at 1424440_at 1447585_s_at 1435862_at 1423707_at -0.Poloxamer 407 Epigenetics 02 0.Vitexin Protocol 68 0.71* 0.78 0.39 0.67* 0.64 0.81* 1.00*** 0.68 0.80 0.36 0.46 0.73 1.22 0.81 -1.19** 1.01* 0.76 -0.21 0.64* 1.20* 0.77* 0.61 0.99* 0.96*** -0.07 0.37 0.64* 0.26 0.70* 0.46 0.95** 0.65 0.68* -0.94 -1.12 0.16 1.12* 1.49* 1.49* 0.83 -0.64 0.48 -0.54 0.57 0.66* 0.51 0.72* 1.15* 0.20 0.76** -0.07 0.48 0.74* 0.52 0.70* 0.68* 0.72 0.63 0.85** 4.72* five.77* 0.64 0.84 0.91 0.84 0.92* -1.04* 0.97* 0.18 1.07* 0.78** 0.55 0.64 0.91 0.58 0.84* 0.39* 1.09*** 0.94*** 1.11*** 0.91*** 0.22 0.74* 0.92** 0.77** 0.80 1.10 0.82** 0.75 0.50 0.62 1.43*** -1.14** 1.04** 1.67* -0.06 0.99*** 1.45** 0.91** 0.61 1.17** 0.99*** -1.11 0.38 0.96 -0.16 -1.26** -0.23 0.17 0.31 -0.92* 0.36 0.07 0.45 -0.80* 0.73* 0.66 0.85* 0.07 0.08 0.43 0.50 0.24 -0.08 0.57 0.51 0.04 -0.08 0.30 0.34 -0.16 -1.27 0.10 0.25 0.42 0.34 0.55* five.36* 0.51 0.41 0.61* 0.89** 0.55 1.68 0.31 0.57* 0.66 -0.36 0.33 0.45 0.64 0.23 0.39 0.59 -0.16 -0.02 -0.02 0.Mrps6 Son Tmem50bMitochondrial ribosomal protein S6 Son cell proliferation protein Transmembrane protein 50B0.PMID:28739548 46 0.73 0.0.50 0.07 -0.0.55 0.44 0.61*0.38 0.84** 0.Ling et al. BMC Genomics 2014, 15:624 http://www.biomedcentral/1471-2164/15/Page 15 ofTable 3 Summary of spatiotemporal RT-qPCR validations of 25 chosen DEGs (Continued)Ttc3 Wrb Tetratricopeptide repeat domain 3 Tryptophan rich standard protein 1448361_at 1460446_at 0.33 0.56 0.63** 0.85** 0.45 0.69 0.46 0.70* 0.34 1.00 0.37 0.26 0.50 0.44 0.37 0.63*All chosen DEGs are trisomic genes situated on chromosome 16 except for Erdr1 (a disomic gene located on chromosome X), Itgb8 (a monosomic gene situated on chromosome 12), Sod1 (a trisomic gene situated on chromosome 16, though one of the copies is non-functional because of truncation), and Stat1 (a disomic gene situated at chromosome 1). *p0.05, **p0.01 and ***p0.001 primarily based on Empirical Bayes t-statistic test.with two other studies around the embryonic Ts1Cje neurosphere [34] and early postnatal Ts1Cje whole brains [33], but this result is in contrast to those of Laffaire et al. [23], who observed Dyrk1a over-expression within the cerebellum of early postnatal Ts1Cje mice. In line with our dataset, Rcan1, which is located within the Down syndrome important region (DSCR), was over-expressed in P1 c.
