Product Name :
MD2-TLR4-IN-1
Description:
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.
CAS:
2249801-12-3
Molecular Weight:
421.28
Formula:
C22H14Cl2N4O
Chemical Name:
2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]benzamide
Smiles :
O=C(NC1C=C2C(=NNC2=CC=1)C1C=C2C=CNC2=CC=1)C1C(Cl)=CC=CC=1Cl
InChiKey:
AZPDJGLJPDRCDQ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H14Cl2N4O/c23-16-2-1-3-17(24)20(16)22(29)26-14-5-7-19-15(11-14)21(28-27-19)13-4-6-18-12(10-13)8-9-25-18/h1-11,25H,(H,26,29)(H,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Penicillin-Streptomycin} MedChemExpress|{Penicillin-Streptomycin} Activator|{Penicillin-Streptomycin} Technical Information|{Penicillin-Streptomycin} In stock|{Penicillin-Streptomycin} manufacturer}
Additional information:
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.{{Doxazosin} web|{Doxazosin} Autophagy|{Doxazosin} Biological Activity|{Doxazosin} Data Sheet|{Doxazosin} custom synthesis|{Doxazosin} Epigenetics} 89 μM and 0.PMID:32941744 53 μM, respectively.|Product information|CAS Number: 2249801-12-3|Molecular Weight: 421.28|Formula: C22H14Cl2N4O|Chemical Name: 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]benzamide|Smiles: O=C(NC1C=C2C(=NNC2=CC=1)C1C=C2C=CNC2=CC=1)C1C(Cl)=CC=CC=1Cl|InChiKey: AZPDJGLJPDRCDQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H14Cl2N4O/c23-16-2-1-3-17(24)20(16)22(29)26-14-5-7-19-15(11-14)21(28-27-19)13-4-6-18-12(10-13)8-9-25-18/h1-11,25H,(H,26,29)(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (197.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
